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All five AIDS-related PCNSLs expressed LMP-1(>40%),EBNA-2(>60%),and VCA(1 to 5%)of tumor cells.These proteins were similarly expressed in the SCID/ human chimeras.None of the PCNSLs from immunocompetent subjects,the normal brain,or the brain of the patient with PML expressed these proteins.PCNSL in AIDS patients bears greater similarity to EBV-infected LCLs than to PCNSL from immunocompetent patients. |
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